Cell scientist to watch - Mitchell Guttman.

نویسنده

  • Mitchell Guttman
چکیده

Mitchell received a bachelor's degree in molecular and computational biology and a master's degree in computational biology and bioinformatics from the University of Pennsylvania. He then joined the laboratory of Eric Lander at the Broad Institute of MIT and Harvard and was awarded his PhD in 2012. The same year he was named in the Forbes '30 under 30: science and healthcare' list of rising stars and received an NIH early independence award. Mitchell subsequently moved to the California Institute of Technology as an Assistant Professor to establish his own laboratory. He has received numerous awards, including being named a Robertson Investigator of the New York Stem Cell Foundation, an Investigator at the Heritage Medical Research Institute and a Pew-Stewart scholar for cancer research in 2015. Having identified and characterised a new class of functional large non-coding RNA (lncRNA) genes, his laboratory aims to understand the mechanisms by which lncRNAs act to control cellular functions through regulation of proteins, binding to genomic DNA targets and contributing to nuclear organisation.

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منابع مشابه

RNA and dynamic nuclear organization: Long noncoding RNAs may function as organizing factors that shape the cell nucleus

John Rinn1,2,3 and Mitchell Guttman4 John Rinn: [email protected]; Mitchell Guttman: [email protected] 1Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA 2Beth Israel Deaconess Medical Center, Boston, MA 02215, USA 3Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA 4Division of Biology and Biological Engineering, California Institute of Techno...

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A Guide to Packing Your DNA

Genetic material is not randomly organized within the nucleus of a cell. How this organization occurs and why it matters are questions that Cell editor Marta Koch posed to Mitchell Guttman, Job Dekker, and Stavros Lomvardas. Excerpts from this Conversation are presented below, and an audio file of the full discussion is available with the article online.

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Linking Protein and RNA Function within the Same Gene

Exposure to ultraviolet light leads to a cell-wide DNA damage response that includes a global reduction in transcription. Williamson et al., identify a protein involved in this process as well as a noncoding RNA produced by alternative processing of RNA transcribed from the same gene that promotes recovery from the repressed state.

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RNA antisense purification (RAP) for mapping RNA interactions with chromatin.

RNA-centric biochemical purification is a general approach for studying the functions and mechanisms of noncoding RNAs. Here, we describe the experimental procedures for RNA antisense purification (RAP), a method for selective purification of endogenous RNA complexes from cell extracts that enables mapping of RNA interactions with chromatin. In RAP, the user cross-links cells to fix endogenous ...

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Cell scientist to watch - Megan King.

Megan king received her BA in biochemistry from Brandeis University and then pursued a PhD degree in Biochemistry and Molecular Biophysics at the University of Pennsylvania working in the group of Mark Lemmon. For her postdoctoral training, Megan chose the laboratory of Günter Blobel at the Rockefeller University in New York. Since starting her own group at the Cell Biology Department at Yale S...

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عنوان ژورنال:
  • Journal of cell science

دوره 130 9  شماره 

صفحات  -

تاریخ انتشار 2017